A New Theory-Based Treatment For ALS
Taking a “micro-dose” of 0.04 mg dexamethasone daily has the potential to stop the continuing motor neuron destruction that leads to the progressive disability and early death in patients with ALS.
This website presents a complete theory of the initiation and progression of ALS involving systemic immune cells leaking through a damaged Blood Brain Barrier (BBB). Dexamethasone at the extremely low dose of 0.04 mg daily heals the BBB.
At 0.04 mg dexamethasone daily, there are no adverse steroid effects that are present at the usual high doses used for autoimmune diseases like M.S. or asthma. This 0.04 mg daily dose can be taken indefinitely by anyone without any noticeable side effects.
The 0.04 mg dose is calculated to keep the serum dexamethasone level below 1 ng/ml, which has no physiological effect.
The medical and ALS patient community firmly believe at the moment that ALS is degenerative, and steroids don’t work. Challenging these beliefs is difficult, but not impossible.
“A man with a conviction is a hard man to change. Tell him you disagree and he turns away. Show him facts or figures and he questions your sources. Appeal to logic and he fails to see your point.”
― Leon Festinger, A Theory of Cognitive Dissonance
“In science it often happens that scientists say, ‘You know that’s a really good argument; my position is mistaken,’ and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn’t happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day.”
― Carl Sagan